citations.bib

@article{10.4049/jimmunol.178.5.3107,
    author = {Goodridge, Helen S. and Simmons, Randi M. and Underhill, David M.},
    title = "{Dectin-1 Stimulation by Candida albicans Yeast or Zymosan Triggers NFAT Activation in Macrophages and Dendritic Cells1}",
    journal = {The Journal of Immunology},
    volume = {178},
    number = {5},
    pages = {3107-3115},
    year = {2007},
    month = {03},
    abstract = "{Innate immune pattern recognition receptors play critical roles in pathogen detection and initiation of antimicrobial responses. We and others have previously demonstrated the importance of the β-glucan receptor Dectin-1 in the recognition of pathogenic fungi by macrophages and dendritic cells and have elucidated some of the mechanisms by which Dectin-1 signals to coordinate the antifungal response. While Dectin-1 signals alone are sufficient to trigger phagocytosis and Src-Syk-mediated induction of antimicrobial reactive oxygen species, collaboration with TLR2 signaling enhances NF-κB activation and regulates cytokine production. In this study we demonstrate that Dectin-1 signaling can also directly modulate gene expression via activation of NFAT. Dectin-1 ligation by zymosan particles or live Candida albicans yeast triggers NFAT activation in macrophages and dendritic cells. Dectin-1-triggered NFAT activation plays a role in the induction of early growth response 2 and early growth response 3 transcription factors, and cyclooxygenase-2. Furthermore, we show that NFAT activation regulates IL-2, IL-10 and IL-12 p70 production by zymosan-stimulated dendritic cells. These data establish NFAT activation in myeloid cells as a novel mechanism of regulation of the innate antimicrobial response.}",
    issn = {0022-1767},
    doi = {10.4049/jimmunol.178.5.3107},
    url = {https://doi.org/10.4049/jimmunol.178.5.3107},
    eprint = {https://journals.aai.org/jimmunol/article-pdf/178/5/3107/1235777/zim00507003107.pdf},
}